Wheals are NOT commonly caused by:

Wheals, which are raised, itchy areas of skin often associated with an allergic reaction, are typically triggered by factors like allergies, insect bites, and skin irritations. These conditions can lead to a localized immune response resulting in the formation of wheals.

Acne, on the other hand, is primarily a result of clogged pores, bacteria, and inflammation related to oil production in the skin. While acne can lead to various types of skin lesions, it does not typically cause the formation of wheals. Wheals are specifically associated with hives and allergic reactions, making this particular option the best choice for what wheals are not commonly caused by. Understanding the pathophysiology of wheals highlights that while they do present different types of skin reactions, the mechanisms behind acne do not align with how wheals form.